体外膜氧合救治急性重症胰腺炎合并ARDS患者的临床研究

目的:探讨体外膜氧合救治急性重症胰腺炎合并急性呼吸窘迫综合征(ARDS)患者的临床疗效.方法:使用美国百特公司BM-25床边血液净化仪,宁波亚泰公司FDMO-08中空纤维膜式氧合器,对10例急性重症胰腺炎(SAP)合并ARDS的患者进行治疗,观察治疗前后患者血氧分压、二氧化碳分压的变化.结果:10例患者中,6例好转,4例死亡.治疗前后患者的低氧血症有明显改善(P＜0.05).治疗前后动脉血二氧化碳分压无明显改变(P＞0.05).结论:体外膜氧合(ECMO)能迅速、有效提高急性重症胰腺炎合并ARDS患者的血氧浓度,提高SAP的抢救成功率.

Clinical Study of Extracorporeal Membrane Oxygenation in the Treatment of Acute Respiratory Distress Syndrome Secondary to Severe Acute Pancreatitis

Objective:To investigate the effect of extracorporeal membrane oxygenation in the treatment of acute respiratory distress syndrome secondary to severe acute pancreatitis (SAP).Methods:BM25 machine (Baxter, USA) and FDMO-08 hollow-fiber membrane oxygenator(Ningbo Yatai medical Instrument co. ltd) were used for the treatment of 10 patients with ARDS complicating SAP. Partial Pressure of Oxygen( PO_2) and carbondioxide( PaCO_2) were analyzed before and after treatment.Results:Clinical symptoms were singly improved in 6 out of 10 patient and 4 patients died. Hypoxemia was improved after treatment compared with that of before treatment (P<0.05), but there was no significant difference in PaCO_2 (P>0.05).Conclusion:Extracorporeal membrane oxygenation can effectively and rapidly increase the blood oxygen concentration of patients with severe ARDS complicating acute pancreatitis.