Neonatal hyperthyroidism in a premature infant born to a mother with Grave's disease] |
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| Authors: | C Nicaise C Gire V Brémond P Minodier F Soula C d'Ercole C Palix |
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| Affiliation: | Service de pédiatrie et néonatologie, CHU Nord, chemin des Bourrelys, Marseille, France. |
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| Abstract: | BACKGROUND: Neonatal thyrotoxicosis is most commonly due to transplacental transfer of maternal thyroid-stimulating hormone receptor antibodies (TRAb). Bioassay of thyrotropin receptor antibodies may help to determine the risk for neonatal hyperthyroidism. CASE REPORT: Thyrotoxicosis developed in a premature infant born to a mother with Graves' disease, with a low level of TRAb by bioassay. The infant was treated with carbimazole for two months, until TRAb had disappeared. CONCLUSION: Bioassay TRAb is not always reliable for predicting the development of neonatal hyperthyroidism in infants born to mothers with Graves' disease. Thyroid function should be measured in all these neonates. |
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