| 白细胞介素-1受体拮抗剂与骨性关节炎的关系 |
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| 引用本文： | 葛广勇,赵建宁.白细胞介素-1受体拮抗剂与骨性关节炎的关系[J].医学研究生学报,2007,20(10):1084-1087. |
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| 作者姓名： | 葛广勇 赵建宁 |
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| 作者单位： | 1. 南京市江宁医院骨科
2. 南京军区南京总医院(南方医科大学南京临床医学院)骨科,江苏南京,210002 |
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| 摘 要： | 骨性关节炎(OA)是以关节软骨的合成与降解失衡导致软骨丢失为特点的慢性疾病。白细胞介素-1(IL-1)在其发病过程中发挥了重要作用,而作为IL-1特异性的天然拮抗物白细胞介素-1受体拮抗剂(IL-1Ra)越来越受到广泛的重视。作者对IL-1Ra与OA的关系作一综述。
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| 关 键 词： | 白细胞介素-1 白细胞介素-1受体拮抗剂 骨性关节炎 |
| 文章编号： | 1008-8199（2007）10-1084-04 |
| 收稿时间： | 2006-03-17 |
| 修稿时间： | 2006-05-11 |
Correlation between osteoarthritis and interleukin-1 receptor antagonist |
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| GE Guang-yong,ZHAO Jian-ning.Correlation between osteoarthritis and interleukin-1 receptor antagonist[J].Bulletin of Medical Postgraduate,2007,20(10):1084-1087. |
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| Authors: | GE Guang-yong ZHAO Jian-ning |
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| Institution: | Department of Orthopaedics, Nangiing General Hospital of Nanjing Military Comand, PLA, School of Medicine, Southern Medical University, Nangiing 210002, Jiangsu, China |
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| Abstract: | The hallmark of osteoarthnitis(OA) is the loss of articular cartilage caused by an imbalance between cartilage synthesis and degredation over a variable period of time.IL-1 plays an important role in the course.The IL-1receptor antagonist(IL-Ra) specific against IL-1 is becoming a pivot of wide attention.The article offers a review of the relationship between the IL-1Ra and OA. |
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| Keywords: | Interleukin-1 Interleukin-1 receptor antagonist Osteoarthritis |
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