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Studies on the effects of heterologous antisera against subcellular thymocyte fraction |
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| Authors: | Hiroshi Yamamoto Kohki Konomi Sharad D. Deodhar |
| Affiliation: | (1) Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan;(2) Department of Immunology, Cleveland Clinic, 44106 Cleveland, Ohio, USA |
| Abstract: | Subcellular fractions of mice thymocytes were used for sensitization of rabbits. The antisera were examined for their immunosuppressive potency in vivo by allogeneic murine tumor metastases system and on skingraft survival and in vitro by leukocyte agglutination tests. The results indicated that the most potent immunosuppressive antisera was that against the second fraction (Fr. 2) of the detergent soluble endoplasmic reticulum fraction from thymocytes. |
| Keywords: | heterologous antisera anti-thymocyte serum anti-lymphocyte serum subcellular thymocyte fraction immunosuppressive potency leukoagglutination titer allogeneic murine tumor metastases system skin allograft test endoplasmic reticulum fraction microsome fraction |
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