High dose inhaled fluticasone propionate improves FEV1 and results in reduction of oral glucocorticoid dose in glucocorticoid-dependent children with severe asthma. |
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Authors: | S A McMurtry S R Nimmagadda |
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Institution: | Division of Allergy, Children's Memorial Hospital, Chicago, Illinois, USA. |
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Abstract: | A retrospective chart review was performed on eight pediatric patients with glucocorticoid (GC)-dependent asthma who had been switched to fluticasone propionate (FP). A significant increase was noted in average forced expiratory volume in 1 second (FEV1) and forced expiratory flow 25-75% (FEF25-75) at 6 and 12 months. Significant reductions were noted in the oral GC dose at 6 and 12 months with a reduction at 12 months of almost 16.5 mg/day or 65% of the initial oral GC dose. This study suggests that high-dose FP use in children with oral GC-dependent asthma has oral GC sparing effects while improving FEV1 and FEF25-75. |
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