经皮腔内冠状动脉成形术和(或)冠状动脉支架术后纤溶的变化

目的 :认识经皮腔内冠状动脉成形术 (PTCA)和 (或 )冠状动脉支架术 (Stent)后纤溶功能的变化特点 ,探讨其变化对近期治疗结果的影响。方法 :纤溶指标包括纤溶酶原 (PLG)、组织型纤溶酶原活化剂 (t PA)、纤溶酶原活化物抑制剂 (PAI)。在常规使用抗血小板药与抗凝剂的情况下 ,比较 71例患者PTCA和 (或 )Stent后16h及 1周与术前PLG、t PA及PAI的变化。观察术后是否存在冠状动脉血栓形成的情况。结果 :纤溶功能术后 16h明显增强 ,1周时基本恢复。未见术后冠状动脉血栓形成的患者。结论 :术后短时间内纤溶活性明显增强有利于避免冠状动脉内血栓形成。

The clinical study on changes of fibrinolysis after percutaneous transluminal coronary angioplasty and (or) coronary stenting

Objective: To recoganize the characteristic of fibrinolytic function after percutaneous transluminal coronary angioplasty PTCA and (or) coronary stenting (Stent), and explore the immediate effect of the changes of fibrinolytic function.Method: Fibrinolytic parameters included plasminogen (PLG) activity, tissue plasminogen activator (t PA) activity and plasminogen activator inhibitor (PAI) activity. The changes of these parameters at the time of before operation, 16 hours and 1 week after operation were compared in 71 patients. We also observed whether coronary thrombi occurred in these patients. Result: Fibrinolytic function evidently increased at 16 hour and recovered at 1 week. Conclusion: Increase of fibrinolytic function within short period is benefit to avoid coronary thrombi forming.