Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
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| Authors: | Francesco Palmese Rossella Del Toro Giulia Di Marzio Pierluigi Cataleta Maria Giulia Sama Marco Domenicali |
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| Affiliation: | 1.Department of Internal Medicine, AUSL della Romagna, S. Maria delle Croci Hospital, 48121 Ravenna, Italy; (F.P.); (R.D.T.); (P.C.); (M.G.S.);2.Endocrinology and Diabetes Unit, Campus Bio-Medico University of Rome, 00128 Rome, Italy;3.Department of Experimental and Clinical Medicine, University of Florence, Careggi University Hospital, 50139 Florence, Italy;4.Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy |
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| Abstract: | Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions. |
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| Keywords: | sarcopenia, vitamin D, Crohn’ s disease, inflammatory bowel disease, nutritional assessment, malnutrition, skeletal muscle function |
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