Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy |
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Authors: | Mickael Aubignat Melissa Tir Pierre Krystkowiak Daniela Andriuta |
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Affiliation: | 1.Department of Neurology and Center of Expertise in Parkinson’s disease, University Hospital of Amiens, CHU Amiens-Picardie, 80 054 Cedex 1 Amiens, France ;2.Laboratory of Functional Neurosciences (EA 4559), University Hospital of Amiens, Amiens, France |
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Abstract: | BackgroundEpisodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro’s syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor.Case presentationWe report a rare case of Shapiro’s syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson’s disease woman.ConclusionsIn the literature, apart from Shapiro’s syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson’s disease. |
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Keywords: | Headache, Hypothermia, Hyperhidrosis, Shapiro’ s syndrome, Parkinson’ s disease, Clonidine |
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