高尿酸血症与良性前列腺增生的相关性研究

目的探讨高尿酸血症（HUA）与良性前列腺增生（BPH）的相关性。方法选择2010年5月往我院体检中心体检的老年男性共666例，测量血压、腹围，现场询问病史和进行同际前列腺症状评分（IPSS），检测空腹血尿酸、TG、TC、LDL—C、HDL—C、空腹血糖、餐后2小时血糖和血清PSA等，超声测量及计算前列腺体积。按咖尿酸是否〉420gmol／L分为HUA组（n=151）和血尿酸正常组（n=515）。比较两组代谢指标及前列腺相关指标的差片，斤采用logistic回归模型分析HUA与各临床指标的相关性。结果HUA与腹型肥胖OR=1．575，95％CI（1．059，2．340）]、高TG血症OR=2．78，95％CI（1．877，4．118）]、代谢综合征（CDS2007）OR=1．912，95％CI（1．267，2．885）]、BPHOR=1．464，95％CI（1．465，1．635）]及下尿路症状评级OR=1．782，95％CI（1．173，1．522）惰明显相关性性（P〈0．05）。结论HUA与BPH具有明显相关性，且同时伴发其他心血管危险因素风险高，因此，在诊治其中一种疾病时应重视其他危险因素的筛查及管理。

Correlation between Hyperuricemia and Benign Prostatic Hyperplasia

Objective To evaluate the correlation between hy-peruricemia （HUA） and benign prostatic hyperplasia （BPH）. Methods A total of 666 elderly male patients, who had been admitted to the West China Hospital for routine physical examination in May, 2010, were included in this study. All the following indexes were collected： blood pressure, waistline, medical history, international prostatic symptom score （IPSS）, serum uric acid （UA）, triglycerides （TG）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, fasting blood glucose （FBG）, 2-hour postprandial blood glucose （PBG-2）, prostate-specific antigen （PSA）, and prostate volume （PV） measured by ultrasound. Patients with higher level of UA more than 420μmol/L were included into the HUA group （n=151） while the other patients with normal UA （NUA） were in the NUA group （n=515）. Both the metabolic and pros- tate related indexes in the two groups were compared, and the correlation between HUA and each indexes were analyzed using logistic regression model. Results HUA was significantly associated with abdominal obesity （OR=1.575, 95%CI 1.059 to 2.340）, hypertriglyceridemia （OR=2.78, 95%CI 1.877 to 4.118）, metabolic syndrome （CDS2007） （OR=1.912, 95%CI 1.267 to 2.885）, BPH （OR=1.464, 95%CI 1.465 to 1.635） and lower urinary tract symptoms （LUTS） rating （OR=1.782, 95%CI 1.173 to 1.522）. Conclusion HUA is correlated with BPH, meanwhile it is highly accompanied with other risk factors of cardioascular diseases. Hereby, comprehensive medical screening should be considered when treating such patients.