血清CA15-3、CEA及全身骨显像联合检查对乳腺癌骨转移的诊断价值

目的 探讨血清糖类抗原15-3(carbonhydrate antigen 15-3,CA15-3)、癌胚抗原(carcinoembryonic antigen,CEA)测定联合全身骨显像(WBS)对提高乳腺癌骨转移诊断的临床价值。方法 对92例乳腺癌患者分别进行血清CA15-3、CEA检测和WBS,并进行对比分析。结果 乳腺癌骨转移组,血清CA15-3和CEA水平显着增高,与无骨转移的乳腺癌组比较有统计学差异(CA15.3:t=91.8342;CEA:t=77.6323,P<0.01)。CA15-3、CEA及全身骨显像联合检测对诊断乳腺癌骨转移其灵敏度、特异度分别为95.74%、88.89%,较单独检测某项指标诊断效率均有提高。结论 血清CA15-3、CEA及全身骨显像联合检测可提高乳腺癌骨转移的诊断效率,特别是全身骨显像结果模棱两可时意义更大。

The diagnostic significance of CA15-3,CEA combined with whole body bone scan for bone metastases in patients with breast cancer

Objective To investigate the diagnostic significance of carbonhydrate anitigen 15-3,(CA15-3),carcinoembryonic antigen(CEA)combined with whole body bone scan(WBS)for bone metastases in patients with breast cancer.Methods Serum levels of CA153 and CEA were measured and WBS was performed in 92 breast cancer patients.Results Serum levels of CA153 and CEA were higher in bone metastases group than in without bone metastases group significantly(CA15.3:t=91.8342;CEA:t=77.6323,P<0.01).The sensitivity and specificity of combined determinations of CA153,CEA and WBS were 95.74%and 88.89% respectively.Its diagnostic efficiency was higher than any one of them.Conclusion The combined detection of CA153,CEA and WBS can improve the diagnostic efficiency of bone metastases in patient with breast cancer,especially when the results of bone scanning is equivocal.