Antitumor effect of CPT-11, a new derivative of camptothecin,against pleiotropic drug-resistant tumors in vitro and in vivo |
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Authors: | Takashi Tsuruo Takeshi Matsuzaki Miyuki Matsushita Harumi Saito Teruo Yokokura |
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Institution: | (1) Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro, 170 Toshima, Tokyo, Japan;(2) Yakult Central Institute for Microbiological Research, Yaho, 186 Kunitachi, Tokyo, Japan |
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Abstract: | Summary CPT-11, a new derivative of camptothecin, was effective against tumor cells, especially vincristine (VCR)-and adriamycin (ADM)-resistant P388 leukemia, compared to either VCR or ADM. The drug showed superior chemotherapeutic effects over VCR and ADM in sensitive P388 leukemia-bearing mice, and was also effective in VCR-and ADM-resistant P388 leukemia-bearing mice. These latter survival advantages with CPT-11 were almost equal to those obtained by CPT-11 against sensitive P388 leukemia. CPT-11 was found to be effective against human tumor cells, especially various pleiotropically drug-resistant human tumor lines, compared to VCR and ADM. CPT-11 should be considered for further development as a new chemotherapeutic agent potentially effective against pleiotropically drug-resistant tumors. |
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