Relationship between serum bilirubin and coagulation test results in 1-month-old infants |
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Authors: | Filiz Tiker Berkan Gürakan Aylin Tarcan |
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Institution: | (1) Faculty of Medicine, Department of Pediatrics, Baskent University, Turkey |
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Abstract: | Objective: Although the connection between cholestasis and conjugated hyperbilirubinemia is well known, mild hepatic dysfunction or
cholestasis may also be associated with unconjugated hyperbilirubinemia in some infants with prolonged jaundice. The aim of
this study was to investigate the relationship between serum bilirubin levels and alanine aminotransferase levels, asparte
aminotransferase levels, prothrombin time, activated partial thromboplastin time and international normalization ratio findings
in a group of infants.Methods: The study included 77 healthy, term, breast-fed infants with jaundice and 56 age-matched, healthy, term, non-jaundiced controls.
The 133 babies were divided into three subgroups according to their total bilirubin levels group I (controls) <50 μmol/L,
group II=50–100 μmol/L, and group III >100 μmol/L, and the findings for the noted parameters were compared].Results: The mean conjugated bilirubin level was significantly higher, and the mean activated partial thromboplastin time significantly
longer in group III than in group I. A significant positive correlation was found between bilrubin levels and PT and APTT
results.Conclusion: Clinical vitamin K deficiency appeared unlikely to develop in this group of infants with prolonged unconjugated hyperbilirubinemia.
However, a significant positive correlation between bilirubin levels and PT and APTT suggest that a higher bilirubin load
to the liver may cause some degree of vitamin K deficiency due to mild cholestasis. The importance of this finding, and the
possible benefits of vitamin K supplementation in 1-month-old breast-fed infants with bilirubin levels higher than 100 μmol/L
require further investigation. |
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Keywords: | Cholestasis Coagulation Vitamin K deficiency Prolonged unconjugated hyperbilirubinemia |
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