PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells. |
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| Authors: | G. Bkaily, P. d'Orl
ans-Juste, R. Naik, J. P
rodin, J. Stankova, E. Abdulnour, M. Rola-Pleszczynski |
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| Affiliation: | G. Bkaily, P. d'Orléans-Juste, R. Naik, J. Pérodin, J. Stankova, E. Abdulnour, and M. Rola-Pleszczynski |
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| Abstract: | By the use of fura-2 and digital imaging techniques, [K]o depolarization or PAF (10(-9) M) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) that was insensitive to nifedipine but sensitive to (-)-PN200-110 or to lowering of [Ca]o. The PAF-induced effect on [Ca]i was blocked by the PAF receptor antagonist, WEB2170. Our results suggest that [K]o depolarization and PAF increase [Ca]i via the activation of R-type Ca2+ channels. |
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