乳果糖治疗中风卧床病人便秘的疗效和安全性评价

目的：评价乳果糖治疗中风卧床病人便秘的疗效和安全性。方法：治疗组78例中风卧床便秘病人给予乳果糖口服溶液每次30～50ml，清晨顿服。对照组45例给予果导片0．2g，3次／d，口服。10天为1个疗程。结果：治疗组和对照组的治愈率分别为85．9％（67／78）和66．7％（30／45），好转率分别为11．5％（9／45）和6．7％（3／45）。总有效率分别为97．4％和73．3％，2组比较，差异有统计意义（P〈0．05）。治疗组每周排便次数和排便状况优于对照组（P〈0．05）。不良反应发生率低于对照组（P〈0．05）。结论：乳果糖口服溶液治疗中风卧床便秘病人疗效显著，安全性高。

linical Efficacy and Safety of Lactulose in the Treatment of Patients with Constipation after Stroke

Objective：To evaluate clinical efficacy and safety of lactulose in the treatment of patients with constipation after stroke Methods： 123 patients with constipation after stroke were included in a ten - day controlled triM. The 78 cases in the observed group re- ceived lactulose at a dose of 30 to 50 ml every morning. And another 45 patients of the control group took 0.2g of phenolphthalein three times a day. Results：The cured rate in the observed group and the control group was 85.9% （67/78） and 66.7% （30/45）, the im- provement rate in the observed group and the comrol group was 11.5% （9/45） and 6.7% （3/45）. The total effective rate was 97.4% and 73.3% （ P 〈 0.05 ）. The defecation frequency of the observed group was higher than that of the control group （ P 〈 O. 05 ）, the defe- cation condition increased significantly （ P 〈 0.05） in the observed group. Adverse reaction rate of the observed group was lower than that of the control group （ P 〈 0.05 ）. Conclusion： Lactulose had a significant therapeutic effect in the treatment of patients with constipation after stroke, with lower side effect of toxicity and higher safety.