| 广西人群IL-6基因启动子区rsl800796C／G遗传多态性研究 |
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| 引用本文： | 仇晓文,熊滨,覃纲,李军,黄冰,王海彦,胡东海,黄孔文,廖品琥. 广西人群IL-6基因启动子区rsl800796C／G遗传多态性研究[J]. 右江民族医学院学报, 2013, 0(6): 773-776 |
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| 作者姓名： | 仇晓文 熊滨 覃纲 李军 黄冰 王海彦 胡东海 黄孔文 廖品琥 |
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| 作者单位： | [1]广西医科大学附属肿瘤医院麻醉科,广西南宁530021 [2]广西壮族自治区人民医院重症医学科,广西南宁530021 [3]广西壮族自治区民族医院重症医学科,广西南宁530021 [4]右江民族医学院附属医院重症医学科,广西百色533000 |
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| 基金项目： | 中山市科技计划项目（编号：20132A030） |
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| 摘 要： | 摘要：目的研究白细胞介素-6（Interleukin6，IL-6）基因启动子区rsl800796C／G的等位基因及其基因型在中国广西地区人群中的分布频率，比较其与其他种族的分布差异。方法采用单碱基延伸的PCR技术和DNA测序法检测199名中国广西人群的IL-6基因启动子区rsl800796C／G单核苷酸多态性（singlenucleotidepolymorphism，SNP），并与人类基因组计划（Hapmap）公布的四个人群（非洲人、欧洲人、日本人和北京人）的SNP分型数据做比较，分析其基因型及等位基因的分布频率在这五个人群中的分布差异。结果广西地区人群中IL-6基因启动子区rsl800796C／G基因型及等位基因频率在男女组间比较差异无统计学意义（P〉0．05）。与日本人和北京人比较，IL-6基因启动子区rsl800796C／G基因多态性的分布频率差异无统计学意义（P均〉0．05），但与欧洲和非洲人群比较差异有统计学意义（P均d0．05）。结论在中国广西人群中IL-6基因启动子区rsl800796C／G存在基因多态性，其基因型分布及等位基因分布频率与性别无相关性，但与其他种族人群相比存在明显差异。
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| 关 键 词： | 白细胞介素-6 启动区 遗传 多态性 大陆人口群 |
Genetic polymorphism of rslS00796C/G at the IL--6 promoter region in Guangxi population |
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| Qiu Xiaowen,Xiong-Bin,Qin Gang,Li Jun,Huang Bin,Wang Haiyan,Hu Donghai,Huang Kongwen,Liao Pinhu. Genetic polymorphism of rslS00796C/G at the IL--6 promoter region in Guangxi population[J]. Journal of Youjiang Medical College For Nationalities, 2013, 0(6): 773-776 |
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| Authors: | Qiu Xiaowen Xiong-Bin Qin Gang Li Jun Huang Bin Wang Haiyan Hu Donghai Huang Kongwen Liao Pinhu |
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| Affiliation: | 4 (1. Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China E--mail：53567920@qq. corn 2. Intensive Care Unit of People s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi , China ; 3. Intensive Care Unit of Guangxi Zhuang Autonomous Region Nationality Hospital, Nanning 530021, Guangxi,China; 4. Intensive Care Unit of The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China) |
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| Abstract: | Abstract： Objective To study the distribution of alleIe and genotype frequencies of rs1800796C/G poly- morphism at the interleukin （IL）--6 genetic promoter region in Chinese Guangxi populations, and to compare the different distributions of polymorphism among different races. Methods The rs1800796C/G single nucle- otide polymorphism （SNP） at the IL--6 genetic promoter region was examined by using the polymerase chain reaction--single base extension （PCR--SBE） technique and DNA sequencing methods in 199 Chinese Guangxi populations. Allele and genotype frequencies were analyzed and compared with the other four populations （HapMap--YRI, HapMap--CEU, HapMap--JPT and HapMap--HCB）, which was published by Human Ge- nome Project group （HapMap）. Results There was no significant difference of the frequencies of allele and genotype of rs1800796C/G polymorphism between male and female group （ P ~0.05） in Guangxi population. Compared with HapMap--HCB and HapMap--JPT SNP data, there was no significant difference statistically of the distribution of allele and genotype frequencies of rs1800796C/G polymorphism （ both P 〈0.05）, but there was statistical difference while compared with HapMap--CEU and HapMap--YRI （ both P d0.05）. Conclusion Chinese Guangxi populations carry genetic polymorphism of rs1800796C/G at the IL--6 promoter region. The distribution of allele and genotype frequencies has no correlation with gender, but they are signifi cantly different from other ethnic nonulations |
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| Keywords: | interleukin-- 6 promoter regions genetic polymorphism continental population groups |
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