喉癌患者手术治疗效果及影响因素研究

目的探究并分析手术治疗喉癌患者的效果，以及影响手术效果的因素，为更好的治疗喉癌提供参考依据。方法对本院2003年5月至2008年5月喉癌患者80例的临床资料进行回顾性分析，观察手术治疗效果，并对影响患者预后的因素进行单因素和多因素Logistic回归分析。结果80例患者中1、3、5年的生存率分别为98．75％（79／80）；76．25％（61／80）；51．25％（41／80）。单因素结果显示：年龄、肿瘤的原发部位、是否存在淋巴结转移、肿瘤大小、TNM分期和治疗方式对患者预后影响有着统计学意义（P〈0．01）。多因素Logistic回归分析发现：肿瘤原发部位、淋巴结转移、TNM分期和治疗方式是影响患者预后的独立的危险因素，具有统计学意义（P〈0．05）。结论肿瘤原发部位、TNM分期、淋巴结转移和治疗方式是影响喉癌预后的独立危险因素；喉功能保全性手术是治疗喉癌较为理想的方法。

Study on the influencing factors of surgical treatment of patients with laryngeal cancer

Objective To investigate the influencing factors of surgical treatment of patients with laryngeal cancer. It could provide the better way to treat laryngeal cancer. Methods A total of 80 patients with laryngeal cancer from May 2003 to May 2008 in our hospital were studied. All patients were treated by surgery. The effect of surgery would be observed. The influencing factors and the effect of surgery were ana- lyzed by Logistic. Results A total of 80 patients in the 5-year survival rates were 98. 75% （79/80）, 76. 25% （61/80）, and 51.25% （41/80）. Univariate results showed that age, primary site of the tumor, lymph node metastasis, tumor size, tumor node metastasis （TNM） stage, and treatment modality significant- ly impacted on the prognosis of patients （ P 〈 0.01 ）. Multivariate Logistic regression analysis showed that the primary site of the tumor, lymph node metastasis, TNM staging and therapy were independent prognostic risk factors with a statistically significant difference（ P 〈0. 05）. Conclusions The prognosis of laryngeal cancer is affected by many factors, the primary sites of tumor, TNM staging, lymph node metastasis, and treatment methods were independent prognostic factors. Laryngeal function preservation surgery is an ideal method in the treatment of laryngeal cancer.