轮状病毒肠炎患儿血锌水平变化及补锌治疗的效果观察

目的观察轮状病毒（RV）肠炎患儿血锌水平变化情况及补锌治疗的效果。方法选择RV肠炎患儿128例,随机分为常规治疗组和补锌治疗组各64例。常规治疗组主要给予补液及口服蒙脱石散治疗,补锌治疗组在常规治疗基础上给予葡萄糖酸锌口服液治疗。观察两组治疗前后血锌水平的变化情况,比较两组治疗总有效率、临床症状消失时间及住院天数。结果 RV肠炎补锌组治疗后与治疗前和常规治疗组治疗后比较差异有统计学意义（P〈0.01）;两组总有效率、发热时间、腹泻时间及住院时间比较差异有统计学意义（P〈0.05）;而呕吐持续时间差异无统计学意义（P〉0.05）。结论 RV肠炎对血清锌代谢影响较大,补锌可能是治疗和预防轮状病毒肠炎的一种有效辅助方法。

The change of serum zinc and the efficacy of zinc treatment in children with rotavirus enteritis

Objective To observe the serum zinc levels and the clinical effect of zinc treatment in children with rotavirus（RV） enteritis.Methods The children with RV enteritis were divided into conventional treatment group and zinc treatment group,with 64 cases in each group.The serum zinc content were detected,and the total effective rate,disappeared time of clinical symptoms and the number of days of hospitalization were compared between two groups.Results In RV enteritis zinc group,after and before treatment the difference in serum zinc level was significant.After treatment,there was significant difference in serum zinc level between RV enteritis zinc group and conventional treatment group（P ＆lt; 0.05） ;The difference of total efficiency rate,fever duration,diarrhea duration and hospitalization time between two groups were statistically significant（P ＆lt; 0.05） ;but there was no statistically difference in vomiting duration between the two groups（P ＆gt; 0.05）.Conclusion RV enteritis has a great influence on serum zinc metabolism,zinc supplementation may be an effective auxiliary method for the treatment and prevention of rotavirus enteritis.