我院1998～2002年临床分离菌耐药性现状及合理使用抗生素

目的 对1998～2002年临床分离致病菌药敏结果做综合分析，为临床合理使用抗生素提供科学依据。方法 主要使用VITEK-32全自动微生物分析仪对1998年1月～2002年12月全院患者送检培养呈阳性的标本进行细菌鉴定和药敏试验。少数标本的抗生素敏感性测定采用K-B纸片法。结果 5年间常见细菌对各种抗生素的耐药性都不同程度增强。革兰氏阴性杆菌对亚胺培南最敏感，革兰氏阳性球菌对万古霉素最敏感。耐甲氧西林葡萄球菌和产ESBLs细菌都有逐年增加的趋势。结论 细菌的耐药性越来越强，多重耐药菌也越来越多。我们应重视医院感染，加强耐药检测。合理使用抗生素。

Present status of antibiotic resistance of clinical isolates from 1998 to 2002 and the rational use of antibiotics

Objective To analyze the surveillant results of antibiotics suscep tibility of clinical isolates, and to guide the appropriate use of antibiotics.M ethods The strains isolated from patients during 1997 to the end of 2001 were id entified and drug sensitive tests were performed using automated microbial analy sis system VITEK-32 and K-B methods.Results The antibiotics resistance rates increased during this five years.Imipenem was most sensitive for Gram-negativ e rods,and vancomycin was most sensitive for Gram-positive cocci.While the eme rgence of methicillin resistant staphylococci(MRS) and ESBL producing bacteria i ncreased year after year.Conclusion Confronted with the rapid emergency of nosoc omial multidrug resistant strains presents significant therapeutica challenges a nd therefore,the rational use of antibiotic therapy based on susceptibility test s should be emphasizes.