前S1蛋白在HBV指标中的重要意义 |
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引用本文: | 沈铮,沈霞,高峰.前S1蛋白在HBV指标中的重要意义[J].放射免疫学杂志,2002,15(1):61-62. |
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作者姓名: | 沈铮 沈霞 高峰 |
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作者单位: | 1. 上海第二医科大学附属新华医院检验科,200092 2. 上海新新医学生物工程有限公司 |
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摘 要: | 前S1蛋白是HBV衣壳蛋白的一部分,存在于大分子表面抗原蛋白之中,它是乙肝早期诊断的敏感指标,也反映了乙肝病毒的复制和乙肝病情的活动。本文研究显示,162例非乙肝病人血清中前S1蛋白全部阴性;311例乙肝患者中,前S1蛋白阳性率为38.9%,其中急性乙肝93.8%,慢性活动性肝炎51.2%,在乙肝二对半检测模式中,大三阳中该指标阳性率87.1%,小三阳为32.1%。以HBV DNA检测为标准,前S1蛋白的灵敏度为94.1%等,假阴性5.9%,总符合率93.9%。
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关 键 词: | 前S1蛋白 乙型肝炎 HBV DNA 诊断 |
修稿时间: | 2002年2月10日 |
Significance of Pre S1 Protein as an Important HBV Serological Marker |
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Abstract: | Objective Pre S1 protein, which is a part of HBV encapsulated protein and exists in the macromolesular surface antigen protein, is a sensitive marker for early diagnosis of hepatitis B and a reflection of HBVreplication and activily of pathological condition of hepatitis B as well. In 162 patients without hepatitis B, serology test was negative for pre S1 proteinin all of them, and in 311 patients with hepatitis B of various types, the overall positive rate of pre S1 protein was 38 9% (93 8% for acute hepatitis B and 51 2% for chronic active hepatitis). In the serological test battory of hepatitis B, positive rate of pre S1 protein was 87 1% in patients with positive HbsAg, HbeAg, HbcAb markers, and 32 1% in those with only HbsAg, HbeAb, HbcAb markers showing positive. Taking positive HBV DNA as the dingnostic criterium, sensitivity of pre S1 protein was 94 1%, false negative rate was 5 9% and overall coincidence was 93 9%. |
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Keywords: | Pre S1 protein Hepatitis B HBV DNA |
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