Expression of Cathepsin B and Cystatin C in Human Breast Cancer |
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| Authors: | Masao Yano Kyoji Hirai Zenya Naito Munenori Yokoyama Toshiyuki Ishiwata Yasuo Shiraki Masataka Inokuchi Goro Asano |
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| Affiliation: | (1) Department of Pathology and,;(2) Department of Surgery II, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan, JP;(3) Department of Surgery, Mejiro 3rd Hospital, 2-60-5 Kameari, Katsushika-ku, Tokyo 125-0061, Japan, JP |
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| Abstract: | Cathepsin B, which was originally found to be a lysosomal cysteine protease, is also an important matrix protease. In this study, we investigated the expression of cathepsin B and cystatin C, the strongest inhibitor of cathepsin B, and measured the relative amounts of each in human breast cancer tissues. Cystatin C expression relative to cathepsin B expression was found to be decreased. This finding could be associated with the looseness of cancerous interstitial tissue, which might play a role in cancer invasion and metastasis. This report documents the first simultaneous investigation of cathepsin B and cystatin C in breast cancer tissues. Received: February 23, 2000 / Accepted: November 20, 2000 |
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| Keywords: | Cathepsin B Cystatin C Breast cancer |
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