| 姜黄油抗突变作用机理进一步试验研究 |
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| 引用本文： | 赵泽贞,温登瑰.姜黄油抗突变作用机理进一步试验研究[J].癌变．畸变．突变,1999,11(2):75-77. |
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| 作者姓名： | 赵泽贞 温登瑰 |
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| 作者单位： | 河北医科大学第三医院(赵泽贞，温登瑰，魏丽珍，支惠英)，河北省肿瘤研究所!石家庄0500111(邸海灵) |
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| 摘 要： | 为进一步探讨姜黄油的抗突变作用机理，采用抗突变和致突变同步快速试验法对其做了四种处理方式的试验：Ａ．姜黄油先与已知致突变剂丝裂霉素Ｃ（ＭＭＣ）接触，再加入遇到致突变剂即发生突变的指示菌；Ｂ．姜黄油先与上述指示菌接触，用生理盐水（ＮＳ）洗菌，最后加ＭＭＣ；Ｃ．ＭＭＣ先与指示菌接触，用ＮＳ洗菌，最后加姜黄油；Ｄ．姜黄油、ＭＭＣ和指示菌同时混合接触。以上四种方式在３７℃下接触２０ｍｉｎ后分别做试验。结果
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| 关 键 词： | 姜黄油 抗突变 机理 MMC 试验 |
A STUDY ON THE MECHANISM OF ANTIMUTAGENESIS OF TURMERIC OIL |
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| Abstract: | To understand the mechanism of mutagenesis inhibitory effect of Turmeric oil, the authors designed a series of testing procedures to examine the inhibitory effect by Turmeric oil on the mutagenesis induced by Mitomycine(MMC) in Escherichia Coil lysogenic strain of GY5027 as indicated by GY4015 as following ways: A. GY5027 was added after Turmeric oil and MMC had been put together for 20 minutes. B. Turmeric oil was added after GY5027 had been treated with MMC for 20 minutes. C. MMC was added after GY5027 had been treated with Turmeric oil for 20 minutes. D. GY5027, Turmeric oil and MMC were put into together at the same time. Results found that in all of the above A, B, C and D experimental designs, the mutagnesis was significantly inhibited by Turmeric oil. This indicates that Turmeric oil might be able to inhibit mutagenesis both intercellularly and extracellularly and repair genetic damages caused by genotoxicant. |
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| Keywords: | Turmeric oil Antimutagenesis Mechanism |
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