阿德福韦酯致肾损害2例

2例慢性乙型病毒性肝炎男性患者,年龄为40岁和72岁,因肝功能异常给予阿德福韦酯10mg,1次/d,分别于第3年和第2年后出现肾损害。例1SCr166μmol/L,血磷0.69mmol/L;例2患者SCr124μmol/L,血磷0.61mmol/L,尿蛋白（＋＋）。阿德福韦酯减量至10mg,隔日1次。血生化指标逐渐恢复正常。后来例2因HBVDNA升高自行将阿德福韦酯加量至10mg,1次/d。1个月后SCr119μmol/L,遂再次减量,随后肾功能保持正常。

Renal damage caused by adefovir dipivoxil in 2 patients

Two men with chronic hepatitis,aged 40 and 72 years,were treated with adefovir dipivoxil 10 mg once daily for abnormal liver function. They experienced renal damage in the third and second years,respectively. The patient 1 had a SCr level of 166 μmol/L and a serum phosphorus level of 0. 69 mmol/L; the patient 2 had a SCr level of 124 μmol/L,a serum phosphorus level of 0. 61 mmol/L,and a 2 ＋ urine protein. Adefovir dipivoxil was reduced to 10 mg once every other day,and then their biochemical indices normalized gradually. Later,the patient 2 voluntarily increased adefovir dipivoxil dosage to 10 mg once daily for elevated HBV DNA level. One month later,his SCr level was 119 μmol/L. Subsequently,his renal function returned to within normal range after his dosage reduction again.