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| 盐酸小檗碱结肠控释微丸的制备和体外释放测定 | |
| 引用本文： | 刘倩,郭春红,赵仁永. 盐酸小檗碱结肠控释微丸的制备和体外释放测定[J]. 齐鲁药事, 2007, 26(12): 740-741 |
| 作者姓名： | 刘倩 郭春红 赵仁永 |
| 作者单位： | 1. 中国人民解放军总医院第二临床药局,北京,100853 2. 山东医学高等专科学校,山东,济南,250002 3. 山东省医药工业研究所,山东,济南,250100 |
| 摘 要： | 目的制备盐酸小檗碱结肠控释微丸,并初步研究其体外释放行为。方法采用挤出滚圆法制备盐酸小檗碱微丸,旋转包衣锅Eudragit S100包衣,UV法在不同释放条件下测定释放度。结果及结论盐酸小檗碱结肠控释微丸在体外实验中可满足结肠定位释放的要求,使用该方法制备盐酸小檗碱结肠控释微丸有效、可控。 |
| 关 键 词： | 盐酸小檗碱 结肠控释微丸 体外释放 |
| 文章编号： | 1672-7738（2007）12-0740-02 |
Study on preparation and controlled release characteristics of colon controlled release pellets of berberine hydrochloride in vitro |
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| LIU Qian,GUO Chun-hong,ZHAO Ren-yong. Study on preparation and controlled release characteristics of colon controlled release pellets of berberine hydrochloride in vitro[J]. qilu pharmaceutical affairs, 2007, 26(12): 740-741 | |
| Authors: | LIU Qian GUO Chun-hong ZHAO Ren-yong |
| Abstract: | OBJECTIVE Preparation of colon controlled release pellets of berberine hydrochloride and studied in the vitro release behavior of it.METHODS The pellets were prepared by extrusion spheronization,coating by Eudragit S100,and determining the release of berberine Hydrochloride by UV.RESULTS and CONCLUSION This method was controllable,and the in vitro release of colon release pellets of berberine hydrochloride met the requirements. |
| Keywords: | Berberine hydrochloride colon controlled release pellets in vitro release |
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