| 中药制剂-肌萎灵注射液对神经干细胞的促分化作用 |
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| 引用本文： | 杨萍,王继明,应大君,宋林,李振强,吴以岭. 中药制剂-肌萎灵注射液对神经干细胞的促分化作用[J]. 神经解剖学杂志, 2005, 21(2): 171-174 |
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| 作者姓名： | 杨萍 王继明 应大君 宋林 李振强 吴以岭 |
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| 作者单位： | 第三军医大学,解剖学教研室,重庆,400038;河北医科大学,医药研究院,石家庄,050035 |
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| 基金项目： | 国家十五攻关课题(NO:2001BA701A07-33)资助项目 |
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| 摘 要： | 施加不同浓度的肌萎灵注射液诱导神经干细胞分化7d,应用流式细胞仪和免疫组织化学方法检测神经元特异中间丝蛋白(NF -200)和胶质纤维酸性蛋白(GFAP)的表达,以观察肌萎灵注射液对神经干细胞分化的影响。结果表明: (1)肌萎灵注射液能促进神经干细胞的分化; (2) 1%肌萎灵注射液促进神经干细胞向神经元方向分化。本研究结果提示:中药制剂肌萎灵注射液能促进神经干细胞向神经元方向分化。
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| 关 键 词： | 神经干细胞 肌萎灵注射液 分化 神经元 |
| 修稿时间： | 2004-07-05 |
EFFECTS OF CHINESE TRADITIONAL MEDICINE- JIWEILING INJECTION ON THE DIFFERENTIATION OF NEURAL STEM CELLS |
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| Yang ping,Wang Jiming,Ying Dajun,SONG Lin,Li Zhenqiang,WU Yiling. EFFECTS OF CHINESE TRADITIONAL MEDICINE- JIWEILING INJECTION ON THE DIFFERENTIATION OF NEURAL STEM CELLS[J]. Chinese Journal of Neuroanatomy, 2005, 21(2): 171-174 |
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| Authors: | Yang ping Wang Jiming Ying Dajun SONG Lin Li Zhenqiang WU Yiling |
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| Affiliation: | Yang ping 1,Wang Jiming 2,Ying Dajun 1,Song Lin 1,Li Zhenqiang 1,Wu Yiling 2 |
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| Abstract: | To investigate the effects of Jiweiling (JWL) injection on the differentiation of neural stem cells, flow-cytometer and immunohistochemical staining techniques were used to test the expression of neurofilament-200 (NF-200) and glial fibrillary acidic protein (GFAP) after neural stem cells were induced to differentiation for 7 d by different concentrations of JWL injection. The results showed that (1) JWL injection can facilitate neural stem cells differentiation; (2) 1% JWL injection can induce neural stem cells to differentiate into neurons. The results suggest that JWL injection can enhance the neuron-direction differentiation of neural stem cells. |
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| Keywords: | neural stem cells Jiweiling injection differentiation neurons |
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