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The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture
Authors:Barbara C. Halpern   Brian R. Clark   Dorothy N. Hardy   Richard M. Halpern     Roberts A. Smith
Affiliation:Department of Chemistry, University of California, Los Angeles, Calif. 90024;Department of Medicine, University of California, Los Angeles, Calif. 90024;Department of Molecular Biology Institute, University of California, Los Angeles, Calif. 90024
Abstract:In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.
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