The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture |
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Authors: | Barbara C. Halpern Brian R. Clark Dorothy N. Hardy Richard M. Halpern Roberts A. Smith |
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Affiliation: | Department of Chemistry, University of California, Los Angeles, Calif. 90024;Department of Medicine, University of California, Los Angeles, Calif. 90024;Department of Molecular Biology Institute, University of California, Los Angeles, Calif. 90024 |
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Abstract: | In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die. |
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