| 急性脑梗塞静脉溶栓期间血小板活化状态的动态观察 |
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| 引用本文： | 谢惠芳,田时雨,刘兰平,吴宣富,陈俊抛,叶赛娟.急性脑梗塞静脉溶栓期间血小板活化状态的动态观察[J].南方医科大学学报,1998(3). |
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| 作者姓名： | 谢惠芳 田时雨 刘兰平 吴宣富 陈俊抛 叶赛娟 |
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| 作者单位： | 珠江医院神经内科，珠江医院检验科 |
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| 摘 要： | 目的为了探讨急性脑梗塞患者溶栓过程中血小板活化状态。方法采用ＥＬＩＳＡ法测定了１３例急性脑梗塞患者尿激酶静脉溶栓前后血浆中ＧＭＰ－１４０、血栓素Ｂ２水平的改变。结果脑梗塞急性期血浆ＧＭＰ－１４０、ＴＸＢ２水平明显高于正常人，说明血小板处于高活化状态，尿激酶溶栓期间血浆ＧＭＰ－１４０、ＴＸＢ２升高，血小板再次被激活。结论急性脑梗塞早期静脉溶栓期间纤溶增加的同时伴有血小板再次被激活，这对指导临床用药，提高溶栓成功率具有重要意义
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| 关 键 词： | 脑梗塞 溶栓 血小板活化 |
Alternation of platelet activation status in acute ischemic stroke patients during intravenous thrombolytic therapy |
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| Xie Huifang,Tian Shiyu,Liu Lanping,Wu Xuanfu,Chen Junpao,Ye Saijuan.Alternation of platelet activation status in acute ischemic stroke patients during intravenous thrombolytic therapy[J].Journal of Southern Medical University,1998(3). |
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| Authors: | Xie Huifang Tian Shiyu Liu Lanping Wu Xuanfu Chen Junpao Ye Saijuan |
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| Institution: | Xie Huifang,Tian Shiyu,Liu Lanping,Wu Xuanfu,Chen Junpao,Ye Saijuan Department of Neurology,Zhujiang Hospital,First Military Medical University,Guangzhou 510282 |
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| Abstract: | To explore the patelet activation status in acute ischemic stroke patients during intravenous thrombolytic therapy,we measured the plasma GMP 140 and TXB 2 level in 13 acute ischemic stroke patients before and after intravenous thrombolysis with urokinase(UK) by ELISA.The above indexes were markedly elevated in the early stage in acute stroke patients.It was found that platelets were in high activation status,after thrombolytic treatment,the plasma GMP 140 and TXB 2 leves rose immediately,indicating that there was activation of platelet during the period of thrombolytic treatment in acute ischemic patients. |
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| Keywords: | acute ischemic stroke thrombolysis platelet activation |
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