鲍氏不动杆菌临床分布特征及耐药性分析

目的监测医院近年临床标本鲍氏不动杆菌的分布特点及其耐药情况,以指导临床合理用药。方法2004年1月-2005年12月从患者不同标本分离鲍氏不动杆菌,采用NCCLS标准K-B法对临床常用抗菌药物进行耐药分析,了解其耐药变迁。结果177株鲍氏不动杆菌临床分布以呼吸病区最多（47株,26.6%）,其次为重症监护病房（ICU）（38株,21.5%）;年龄越大,检出率越高;痰标本鲍氏不动杆菌的检出率最高（78.1%）;除亚胺培南、美罗培南、头孢哌酮/舒巴坦保持较高的敏感性,其他药物耐药率均〉60.0%,而且耐药率逐年增高;发现10株泛耐药菌株。结论鲍氏不动杆菌在临床的分离率逐年增加,耐药性逐渐增强,应引起相当的重视。

Characteristics of Clinical Distribution and Antimicrobial Resistance of Acinetobacter baumannii

OBJECTIVE To monitor the characteristics of distribution and drug resistance of Acinetobacter baumannii in our hospital. METHODS A. baumannii isolates were collected in our hospital from Jan 2004 to Dec 2005. Antimicrobial susceptibility testing was performed by disk-diffusion method,according to the standards of NCCLS 2004. RESULTS Totally 177 strains of A. baumannii were distributed clinically in the respiratory unit as the most ones (47 strains, 26.6%), and in ICU as the next (38 strains, 21.5%); the older the age, the higher the appearing rate; the highest appearing rate was from the sputum, up to 78.1%; more than 60% of isolates were resistant to all antimicrobial agents tested except imipenem, meropenem and cefoperazone/sulbactam. However,10 pan-resistant strains were found. CONCLUSIONS With the increasing isolation rate of A. baumannii, its drug resistance increases simultaneously.