氯普鲁卡因在阴部神经阻滞和会阴浸润麻醉中的应用

目的 :评价国产氯普鲁卡因在阴部神经阻滞和会阴浸润麻醉中的临床效应。方法 :足月产妇80人 ,随机分为试验组和对照组 ,每组 4 0例。均行会阴侧切术 ,分别采用氯普鲁卡因注射液和普鲁卡因注射液行阴部神经阻滞麻醉 (10mL)和会阴皮下浸润麻醉 (10mL)。观察麻醉起效时间、痛觉消失和持续时间以及麻醉前 10min、麻醉后 30 ,6 0min的HR ,BP和ECG。并随时记录与药物相关的不良反应。结果 :试验组麻醉起效时间、痛觉消失时间和持续时间分别为 (1.1±s 0 .4 ) ,(2 .3± 0 .8) ,(4 8±16 )min ;对照组为 (1.4± 0 .7) ,(2 .9± 1.4 ) ,(36±13)min ,P <0 .0 5或P <0 .0 1。 2组HR ,BP与注射局麻药前相比无显著差异 ,2组间比较也无显著差异 ,P >0 .0 5。 2组均未出现局麻药毒性反应和过敏反应。结论 :国产氯普鲁卡因是产科病人局部浸润麻醉的合适选择之一。

Application of chloroprocaine in pudendal nerve block and perineum infiltration anesthesia

AIM: To evaluate the clinical efficacy of domestically made chloroprocaine used for pudendal nerve block and perineum infiltration anesthesia. METHODS: Eighty full-term pregnant women with American Society of Anesthesiologists (ASA) 1-2 physical status were randomly and double blindly divided into experimental and control groups with forty in each group. In both groups, chloroprocaine(10 mL) made domestically and procaine(10 mL) were applied for pudendal nerve block and perineum infiltration anesthesia, respectively. Onset of anesthetic action, complete loss of pain sensation and duration of anesthetic action of these two anesthetic agents were observed and recorded. HR, BP and ECG were monitored at moments of 10 min before and 30, 60 min after local anesthesia, respectively. Keep careful watch for any adverse reactions if occurred. RESULTS: Onset of local anesthesia in experimental group began at (1.1±s 0.4) min and complete loss of pain sensation appeared at ( 2.3± 0.8)min significantly which were earlier than those in control group ((1.4±0.7) min and (2.9±1.4)min, respectively, P<0.05). Duration of anesthetic action of chloroprocaine (48±16)min was noticeably longer than that of procaine (36±13)min, P< 0.01.Adverse or hypersensitive reactions were not found together with no changes of vital signs before and after local anesthesia in both groups. CONCLUSION: Chloroprocaine made domestically is a suitable anesthetic for local application in obstetrical patients.