| 归芪方对糖尿病大鼠心肌病变的保护作用 |
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| 引用本文： | 柯浩亮,张莹雯.归芪方对糖尿病大鼠心肌病变的保护作用[J].武汉大学学报(医学版),2009,30(5). |
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| 作者姓名： | 柯浩亮 张莹雯 |
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| 作者单位： | 武汉大学中南医院中西医结合科,湖北,武汉,430071 |
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| 基金项目： | 湖北省卫生厅中医药中西医结合科研课题(编号:2005A126) |
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| 摘 要： | 目的:探讨归芪方对糖尿病(DM)大鼠心肌病变的保护作用及其机制。方法:将21只SD大鼠腹腔注射链脲佐菌素(STZ)建立DM模型,按随机数字表法分为DM模型组(D组)、贝那普利治疗组(B组)、归芪方治疗组(G组)。另7只作为空白正常对照组(N组)。G组给予归芪方4.5 g/(kg.d),B组给予贝那普利片10 mg/(kg.d),D组及N组注射等体积的柠檬酸缓冲液。各组大鼠于第8周末处死,测定各组血糖、血脂、心脏重、体重的改变;观察心肌组织Ⅰ、Ⅲ胶原及血管紧张素Ⅱ(AngⅡ)的表达,荧光定量PCR法检测心肌转化生长因子-β1(TGF-β1)及结缔组织生长因子-β1(CTGFβ-1)mRNA的表达。结果:归芪方改善了血糖、血脂异常及抑制Ⅰ、Ⅲ胶原、血管紧张素Ⅱ(AngⅡ)、TGFβ-1、CTGF-β1mRNA的高表达(P<0.05),且在抑制心肌TGF-β1、CTGFβ-1mRNA方面的表达归芪方优于贝那普利组(P<0.01,P<0.05)。结论:归芪方可调节糖尿病大鼠受损的糖、脂代谢异常,抑制心肌TGFβ-1、CTGFβ-1mRNA的表达,延缓糖尿病心血管并发症的进展。
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| 关 键 词： | 糖尿病 归芪方 心肌病 |
Protective Effect of Guiqi Mixture on Cardiomyopathy in Diabetic Rats |
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| KE Haoliang,ZHANG Yingwen.Protective Effect of Guiqi Mixture on Cardiomyopathy in Diabetic Rats[J].Medical Journal of Wuhan University,2009,30(5). |
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| Authors: | KE Haoliang ZHANG Yingwen |
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| Institution: | KE Haoliang,ZHANG YingwenDept.of Integrated TCM , Western Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective: To investigate the protective mechanism of Guiqi mixture(GM),a traditional Chinese drug which mainly consists of astragalus and angelica,on cardiomyopathy in diabetic rats.Methods: The diabetic animal model was made by single intraperitoneal injection of 60 mg/kg streptozotocin(STZ).A total of 21 SD rats were randomly divided into diabetic model group(D group),benazepril treatment group(B group),and Guiqi treatment group(G group).Another seven rats were set as a normal control group(N group).Afte... |
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| Keywords: | Diabetes Mellitus Guiqi Mixture Cardiomyopathy |
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