Infections in Cirrhosis: A Guide for the Clinician |
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| Authors: | Kirsti A. Campbell Hirsh D. Trivedi Sanjiv Chopra |
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| Affiliation: | 1. Beth Israel Deaconess Medical Center, Boston, Mass;2. Harvard Medical School, Boston, Mass;1. Department of Medicine, University of Maryland Medical Center, Baltimore;2. Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, Md;3. Department of Medicine, Providence VA Medical Center and Alpert Medical School of Brown University, Providence, RI;4. Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC;1. Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn;2. Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn;1. Internal Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, Fla;2. Division of Cardiovascular Disease, Jackson Memorial Hospital, Miami, Fla;1. Department of Internal Medicine IV, Section of Nephrology, Klinikum Wels-Grieskirchen, Austria;2. Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Austria;3. Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria;1. Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland;2. Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland;3. Clinical Pharmacology and Toxicology Division, Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine Department, Geneva University Hospitals, Geneva, Switzerland;4. Center for Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital and University of Lausanne, Lausanne, Switzerland;5. School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland;6. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Switzerland;7. Division of Angiology and Hemostasis, Geneva University Hospitals, Geneva, Switzerland |
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| Abstract: | Cirrhosis contributes significantly to morbidity and mortality worldwide. Infections in patients with cirrhosis are common and significantly impact health-related quality of life. As our understanding of immune dysfunction associated with cirrhosis grows and as rates of drug-resistant organisms increase, the management of infections in cirrhosis has become increasingly nuanced. In this review, we discuss the current understanding of cirrhosis-associated immune deficiency, review the most common infections in patients with cirrhosis, and highlight techniques for the general clinician in the prevention and treatment of infections in this high-risk population. |
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| Keywords: | Cirrhosis Immune dysfunction Infections |
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