Life's Simple 7 and Nonalcoholic Fatty Liver Disease: The Multiethnic Study of Atherosclerosis |
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| Authors: | Ebenezer Oni Oluseye Ogunmoroti Norrina Allen Mouaz H. A-Mallah Ron Blankstein Seth S. Martin Irfan Zeb Mary Cushman Parag H. Joshi Matthew J. Budoff Michael J. Blaha Roger S. Blumenthal Emir Veledar Khurram Nasir |
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| Affiliation: | 1. Division of Cardiology, Heart and Vascular Institute, Albert Einstein Medical Center, Philadelphia, Penn;2. The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Md;3. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill;4. Preventive Cardiology, Houston Methodist DeBakey Cardiology Associates, Houston Tex;5. Departments of Medicine (Cardiovascular Division) and Radiology, Brigham and Women''s Hospital, Boston, Mass;6. Division of Cardiology, Heart and Vascular Institute at West Virginia University Hospital, Morgantown, WVa;7. Departments of Medicine and Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vt;8. Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, Tex;9. Division of Cardiology, Harbor-UCLA Medical Center, Torrance, Calif;10. Corporate Clinical Administration, Baptist Health South Florida, Miami, Fla;1. Division of Emergency and General Medicine, Tokyo Metropolitan Tama Medical Center, Japan;2. Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, Japan;1. Departments of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan;2. Departments of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan;1. Department of General Medicine, Chiba University Hospital, Chiba, Japan;2. Department of General Medicine, Yokohama City University School of Medicine, Kanagawa, Japan |
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| Abstract: | BackgroundThe American Heart Association (AHA) has defined Life's Simple 7 (LS7) as a measure of overall cardiovascular health . Nonalcoholic fatty liver disease (NAFLD) has been involved as a risk factor for cardiovascular disease. We evaluated the association between LS7 and NAFLD.MethodsWe evaluated participants form the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Cardiovascular health score was calculated from the Life's Simple 7 metrics. A score of 0-8 was considered inadequate, 9-10 average, and 11-14 optimal. NAFLD was defined using noncontrast cardiac computed tomography (CT) and a liver/spleen attenuation ratio (L/S) < 1. Multivariable regression were performed to evaluate the association.ResultsOur cross-sectional analysis of 3901 participants showed 19% (n = 747) had optimal cardiovascular health, 33% (n = 1270) had average, and 48% (n = 1884) had inadequate. White participants were most likely to have an optimal score (51%, n = 378), whereas African American participants had the lowest proportion with optimal scores (16%, n = 120; P < 0.001). The overall prevalence of NAFLD was 18% with a distribution of 7%, 14%, and 25% in the optimal, average, and inadequate score categories, respectively (P < 0.001). Adjusted for risk factors, average and optimal health categories had lower odds of NAFLD compared to those with inadequate scores: odds ratio for average, 0.44 (95% confidence interval 0.36-0.54); optimal, odds ratio 0.19 (95% confidence interval 0.14-0.26). This association was similar across gender, race and age groups.ConclusionA more favorable cardiovascular health score was associated with a lower prevalence of NAFLD. This study may suggest a potential of Life's Simple 7 in the prevention of liver disease. |
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| Keywords: | Cardiovascular health Nonalcoholic fatty liver disease Life's Simple 7 |
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