The Use of Colchicine in Cardiovascular Diseases: A Systematic Review |
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| Authors: | Jessica Siak Nir Flint Hezzy G Shmueli Robert J Siegel Florian Rader |
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| Institution: | 1. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif;2. Department of Cardiology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel;3. Smidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, Calif;1. Internal Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, Fla;2. Division of Cardiovascular Disease, Jackson Memorial Hospital, Miami, Fla;1. Department of Internal Medicine IV, Section of Nephrology, Klinikum Wels-Grieskirchen, Austria;2. Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Austria;3. Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria;1. Beth Israel Deaconess Medical Center, Boston, Mass;2. Harvard Medical School, Boston, Mass;1. Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn;2. Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn;1. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Md;2. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md;3. National Institutes of Health Clinical Center, Bethesda, Md;4. University of Mississippi Medical Center, Jackson |
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| Abstract: | The medicinal properties of colchicine have been recognized for centuries. Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease, and 3) atrial fibrillation. We also discuss the safety, potential adverse effects, and common drug interactions that should be considered during use. |
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| Keywords: | Atrial fibrillation Colchicine Coronary artery disease Pericarditis Safety |
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