Physical Frailty Phenotype and the Development of Geriatric Syndromes in Older Adults with Coronary Heart Disease |
| |
| Authors: | Abdulla A Damluji Shang-En Chung Qian-Li Xue Rani K Hasan Jeremy D Walston Daniel E Forman Karen Bandeen-Roche Mauro Moscucci Wayne Batchelor Jon R Resar Gary Gerstenblith |
| |
| Institution: | 1. The Inova Center of Outcomes Research, Inova Heart and Vascular Institute, Falls Church, Va;2. Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Md;3. Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Md;4. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md;5. Geriatric Cardiology Section, University of Pittsburgh, Pittsburgh, Penn;6. Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Penn;7. Food and Drug Administration, Silver Spring, Md;1. Cardiology Fellow, College of Medicine, University of Arizona, Phoenix;2. Cardiology Fellow, College of Medicine, University of Arizona, Tucson;1. Department of Internal Medicine, Medical University of South Carolina, Charleston;2. Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston;3. Digestive Disease Research Center, Medical University of South Carolina, Charleston |
| |
| Abstract: | BackgroundFrailty, a clinical state of vulnerability, is associated with subsequent adverse geriatric syndromes in the general population. We examined the long-term impact of frailty on geriatric outcomes among older patients with coronary heart disease.MethodsWe used the National Health and Aging Trends Study, a prospective cohort study linked to a Medicare sample. Coronary heart disease was identified by self-report or International Classification of Diseases (ICD) codes 1-year prior to the baseline visit. Frailty was measured using the Fried physical frailty phenotype. Geriatric outcomes were assessed annually during a 6-year follow-up.ResultsOf the 4656 participants, 1213 (26%) had a history of coronary heart disease 1-year prior to their baseline visit. Compared to those without frailty, subjects with frailty were older (ages ≥75: 80.9% vs 68.9%, P < 0.001), more likely to be female, and belong to an ethnic minority. The prevalence of hypertension, stroke, falls, disability, anxiety/depression, and multimorbidity were much higher in the frail, than nonfrail, participants. In a discrete time survival model, the incidence of geriatric syndromes during 6-year follow-up including 1) dementia, 2) loss of independence, 3) activities of daily living disability, 4) instrumental activities of daily living disability, and 5) mobility disability were significantly higher in the frail than in the nonfrail older patients with coronary heart disease.ConclusionIn patients with coronary heart disease, frailty is a risk factor for the accelerated development of geriatric outcomes. Efforts to identify frailty in the context of coronary heart disease are needed, as well as interventions to limit or reverse frailty status for older patients with coronary heart disease. |
| |
| Keywords: | Coronary disease Frailty Older adults |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
