胆固醇代谢调控CD8+T细胞抗肿瘤作用的研究进展

CD8+T细胞又名细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL),具有直接杀死病原体感染细胞和癌细胞的作用.然而,CD8+T细胞常常丧失其效应功能,继而限制肿瘤微环境中的抗肿瘤免疫,因此,如何重新激活CD8+T细胞的抗肿瘤效力是目前需要解决的问题.最近研究发现,胆固醇代谢在肿瘤中发挥重要作用...

Research progress on anti-tumor effect of CD8+T cells regulated by cholesterol metabolism

CD8⁺T cells,also known as cytotoxic T lymphocytes or CTL,can directly kill pathogen infected cells and cancer cells.However,CD8⁺T cells often lose their effector function,and then limit the anti-tumor immunity in tumor microenvironment.Therefore,how to reactivate the anti-tumor efficacy of CD8⁺T cells is a problem that needs to be solved.Recent studies have found that cholesterol metabolism plays an important role in tumors.Cholesterol contributes to the accumulation of T cell receptors and the formation of immune synapses,and the effector function of T cells is also affected by its metabolism.Tumor cells can use cholesterol metabolism to induce T cell depletion and escape T cell immune surveillance.At present,the screening of new molecules and strategies for cholesterol metabolism and CD8⁺T cellular immune effect has become a hot spot in the field of tumor research.This paper summarizes the important studies on cholesterol and CD8⁺T cells,and expounds the mechanism of cholesterol metabolism and its anti-tumor activity in CD8⁺T cells,so as to provide reference for follow-up research.