锦州地区妊娠早期女性甲状腺功能的临床分析及参考值的建立#br#

目的分析锦州地区妊娠早期女性甲状腺功能的临床特点及建立参考值。方法选择辽宁省锦州地区150例妊娠早期女性作为研究组,同时选择150例健康非妊娠期女性作为对照组,通过罗氏检验平台检测血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(Tg Ab)以及甲状腺过氧化物酶抗体(TPOAb)水平,随访并记录所有妊娠女性的妊娠结局。结果研究组血清TSH水平低于对照组,血清FT3、FT4、Tg Ab和TPOAb水平均高于对照组(P<0.05)。TSH参考值为(0.07~2.49)m IU/L、FT4参考值为(13.30~20.65)pmol/L。对所有妊娠女性跟踪随访中位数为32周,150例妊娠女性均为活产,其中140例(93.33%)顺产,仅出现早产1例(0.67%)、胎儿宫内窘迫1例(0.67%)、胎儿生长受限2例(1.33%),新生儿出生时体质量为(3212.97±276.75)g,Apgar评分为(9.65±0.22)分。结论锦州地区妊娠早期女性血清TSH水平明显降低,血清FT3、FT4、Tg Ab和TPOAb水平则明显升高,当地需建立妊娠妇女早孕期甲状腺激素正常参考值。

Clinical analysis and reference intervals establishment of thyroid-related indexes of different testing platforms for early pregnancy women in Jinzhou area

Objective?To analyze the clinical characteristics of early pregnancy women's thyroid function in Jinzhou area and establish reference values. Methods?150 women of early pregnancy in Jinzhou area were selected as the study group, and 150 healthy non-pregnant women were selected as the control group. The serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroglobulin antibodies (TgAb) and anti-thyroidperoxidase (TPOAb) were tested by the detection platforms of Roche. All pregnant women and the pregnancy outcome were followed up and recorded. Results?The serum TSH levels in the study group were lower than those in the control group, and serum FT3, FT4, TgAb and TPOAb levels were higher than those in the control group (P＜0.05). The reference value of TSH was (0.07~2.49) mIU/L, and the reference value of FT4 was (13.30~20.65) pmol/L. The median follow-up for all pregnant women was 32 weeks. 150 pregnant women had live births, of which 140 (93.33%) gave vaginal delivery, only 1 case premature delivery (0.67%) and 1 case fetal distress (0.67%), 2 cases fetal growth restriction (1.33%). The birth weight of the newborn was (3212.97±276.75) g, and the Apgar score was (9.65±0.22) points. Conclusions?The serum TSH level of early pregnancy women in Jinzhou area is significantly reduced, while the serum FT3, FT4, TgAb and TPOAb levels are significantly increased. The local reference value of normal thyroid hormone for pregnant women in early pregnancy should be established.