Cardiovascular Effects of Medical Marijuana: A Systematic Review |
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Authors: | Ahmed K. Pasha Charlene Y. Clements Charity A. Reynolds Maegan K. Lopez Ciara A. Lugo Yulisa Gonzalez Farshad M. Shirazi Aiden Abidov |
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Affiliation: | 1. Hospital Internal Medicine, Mayo Clinic Health System, Mankato, Minn;2. Winslow Indian Health Care Center, Winslow, Az;3. Fond Du Lac Human Services Division, Cloquet, Minn;4. Banner University Medical Center, Tucson, Az;5. University of Arizona, Tucson;6. Arizona State University, Phoenix;7. Arizona Poison and Drug Information Center, University of Arizona, Tucson;8. Cardiology Section, John D. Dingell VA Medical Center, Detroit, Mich;1. Professor of Medicine, Department of Medicine, University of Arizona, Tucson;1. Centre d''Investigations Cliniques Plurithématique Inserm 1433, Université de Lorraine, Nancy, France;2. Centre Hospitalier Régional Universitaire (CHRU) de Nancy, Inserm U1116, Nancy, France;1. Department of Internal Medicine IV, Section of Nephrology, Klinikum Wels-Grieskirchen, Austria;2. Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Austria;3. Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria;1. Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn;2. Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn |
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Abstract: | Utilization of marijuana as a medicinal agent is becoming increasingly popular, and so far, 25 states have legalized it for medical purposes. However, there is emerging evidence that marijuana use can result in cardiovascular side effects, such as rhythm abnormalities, syncope/dizziness, and myocardial infarction, among others. Further, there are currently no stringent national standards or approval processes, like Food and Drug Administration (FDA) evaluation, in place to assess medical marijuana products. This review includes the largest up-to-date pooled population of patients with exposure to marijuana and reported cardiovascular effects. Although purported as benign by many seeking to advance the use of marijuana as an adjunctive medical therapy across the country, marijuana is associated with its own set of cardiovascular risks and deserves further definitive study and the same level of scrutiny we apply in research of all other types of medications. When used as a medicinal agent, marijuana should be regarded accordingly, and both clinical providers and patients must be aware of potential adverse effects associated with its use for early recognition and management. |
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Keywords: | Cannabinoids Cardiovascular effects Hemodynamics Marijuana |
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