Effect of insulin on glucagon enhanced lipolysis in vitro |
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Authors: | P. J. Lefebvre A. S. Luyckx |
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Affiliation: | (1) Institut de Médecine, Département de Clinique et de Pathologie Médicales, Secteur Diabétologie, Université de Liège, Belgique |
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Abstract: | Summary Glucagon in concentrations similar to those found in human plasma markedly stimulates lipolysis in rat adipose tissuein vitro. The effects of these physiological concentrations of glucagon are reduced or abolished by insulin at concentrations of 25 and 100U/ml. Considering the marked insulinogenic effect of glucagon these observations may provide an explanation for the delayed increase of blood FFA observed after glucagon injectionin vivo.This work was supported by the Fonds National de la Recherche Scientifique and the Fonds de la Recherche Scientifique Médicale, Belgium. |
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Keywords: | Insulin glucagon adipose tissue lipolysis FFA |
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