Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population |
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| Authors: | Kazuma Kiyotani Makiko Shimizu Toshio Kumai Tetsuya Kamataki Shinichi Kobayashi Hiroshi Yamazaki |
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| Affiliation: | (1) Laboratory for Pharmacogenetics, RIKEN Center for Medicine, Yokohama 230-0045, Japan;(2) Showa Pharmaceutical University, Machida Tokyo, 194-8543, Japan;(3) St. Marianna University School of Medicine, Kawasaki Kanagawa, 216-8511, Japan;(4) Hokkaido University, Sapporo 060-0812, Japan;(5) Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida Tokyo, 194-8543, Japan; |
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| Abstract: | Purpose Although CYP2D6*36 was thought to be one of the alleles causing the poor metabolizer phenotype, several in vitro studies clarified that the enzyme produced by CYP2D6*36 showed enzymatic activities. However, the effects of CYP2D6*36 in tandem with CYP2D6*10 on the in vivo CYP2D6 activity have been unclear. In this study, we investigated in vivo metabolic capacities of CYP2D6 among the subjects carrying different numbers of CYP2D6*36 in tandem with CYP2D6*10. |
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