| 根黄分散片处方工艺及体外溶出度的研究 |
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| 引用本文： | 辛蕊华,罗永江,郑继方,邓素平,王贵波,李维,胡振英.根黄分散片处方工艺及体外溶出度的研究[J].中国实验方剂学杂志,2010,16(16):1-4. |
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| 作者姓名： | 辛蕊华 罗永江 郑继方 邓素平 王贵波 李维 胡振英 |
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| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所,兰州,730050
2. 兰州市疾病预防控制中心,兰州,730030 |
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| 基金项目： | "十一五"国家科技支撑计划项目，中央级公益性科研院所基本科研业务费专项资金项目 |
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| 摘 要： | 目的:优选根黄分散片的处方工艺,并对其溶出行为进行考察。方法:以崩解时限为考察指标,采用正交试验设计筛选出最佳处方,RP-HPLC测定根黄分散片中有效成分的含量,绘制其体外溶出曲线。结果:优选出最佳处方:40%的微晶纤维素(MCC)为填充剂,15%的交联聚乙烯吡咯烷酮(PVPP)和7%的低取代羟丙基纤维素(L-HPC)为联合崩解剂,分散片可在3 min内完全崩解并且全部通过2号筛,在10 min时累积溶出度可达到99%以上。结论:该工艺制备的分散片符合规定,可操作性强、重复性好、适合工业化生产的要求。
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| 关 键 词： | 根黄分散片 正交设计 崩解时限 溶出度 |
| 收稿时间： | 2010/6/27 0:00:00 |
Preparation and In Vitro Dissolution of Genhuang Dispersible Tablet |
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| XIN Rui-hu,LUO Yong-jiang,ZHENG Ji-fang,DENG Su-ping,WANG Gui-bo,LI Wei and HU Zhen-ying.Preparation and In Vitro Dissolution of Genhuang Dispersible Tablet[J].China Journal of Experimental Traditional Medical Formulae,2010,16(16):1-4. |
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| Authors: | XIN Rui-hu LUO Yong-jiang ZHENG Ji-fang DENG Su-ping WANG Gui-bo LI Wei and HU Zhen-ying |
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| Institution: | XIN Rui-hua1,LUO Yong-jiang1,ZHENG Ji-fang1,DENG Su-ping1,WANG Gui-bo1,LI Wei2,HU Zhen-ying1(1.Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,Key Lab of New Animal Drug Project,Chinese Academy of Agricultural Sciences,Lanzhou 730050,China,2.Lanzhou Center for Disease Control and Prevention,Lanzhou 730030,China) |
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| Abstract: | Objective:To optimize the shaping technology of the Genhuang Dispersible Tables and study the release characteristics in vitro.Method:The orthogonal design was used to obtain the optimal formulation with the disintegration of tablets;dissolution method and RP-HPLC method were used to study the release curve in vitro.Result:The proportion of each adjuvant in the optimal formulation consisted of 40% MCC as bulking agent,15% PVPP and 7% L-HPC as disintegrant.The prepared dispersible tables could be totally dis... |
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| Keywords: | Genhuang Dispersible Tablet orthogonal design disintegration time dissolution |
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