| 氯氮平对[^3H]QNB与鼠前脑匀浆特异性结合的影响 |
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| 引用本文： | 耿德勤,胡刚.氯氮平对[^3H]QNB与鼠前脑匀浆特异性结合的影响[J].临床精神医学杂志,1998,8(2):74-76. |
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| 作者姓名： | 耿德勤 胡刚 |
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| 作者单位： | [1]徐州医学院附属医院 [2]徐州医学院神经药理研究室 |
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| 摘 要： | 为探讨氯氮平与毒蕈碱样胆囊受体结合的特性，比较其拮抗胆碱受体的强度，将不同浓度的氯氮平、阿托品、多虑平、酚妥拉明分别与含有标记配基［＾３Ｈ］－二苯羟乙酸奎宁酯（＾３Ｈ－ＱＮＢ）的鼠前脑匀浆进行放射配基结合分析实验。结果发现，氯氮平对毒蕈碱样受体有较强的结合能力，其强度低于阿托品，高于多虑平，Ｋｉ为１６０ｎｍｏｌ／Ｌ。作者认为，氯氮平拮抗胆碱能受体的能力，与其抗精神病药理作用机制有关。
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| 关 键 词： | 氯氮平 QNB 毒蕈碱样受体 鼠脑 |
Effects of clozapine on muscarinic cholinoreceptor binding in rat forebrain |
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| Geng Deqin,et al..Effects of clozapine on muscarinic cholinoreceptor binding in rat forebrain[J].Journal of Clinical Psychological Medicine,1998,8(2):74-76. |
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| Authors: | Geng Deqin |
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| Institution: | Geng Deqin,et al.Department of Neurology and Psychiatry,Xuzhou Medical Callege,Jiangsu 221002 |
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| Abstract: | Objective:To study the affinity of clozapine to muscarinic acetylcholine receptors in the forebrain of rats and the inhibitory potency of clozapine, atropine, doxepine and regitine on QNB specific binding sites. Method:The radio-ligand QNB recepter assays of clozapine, atropine, doxepine and regitine in rat forebrain homogenates were performed. Results:Clozapine was a more potent muscarinic antagonist as compared to doxepin but was less potent than atropine.Its Ki was 160nmol/L. Discussion:The authors viewed that the anti-muscarinic effect of clozapine was related to its antipsychotic effects, especially for negative symptoms in chronic schizophrenic . |
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| Keywords: | Clozapine QNB Muscarinic acetylcholinergic receptors Rat forebrain |
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