Glucagon and insulin secretion in potential diabetes |
| |
Authors: | Antonio Tiengo Domenico Fedele Michele Muggeo Romano Nosadini Maurizio Molinari Maria Chiara Garotti Gaetano Crepaldi |
| |
Institution: | (1) Istituto di Medicina Clinica Divisione di Gerontologia e Malattie del Metabolismo, Università di Padova, Padova, Italy |
| |
Abstract: | Summary Insulin and glucagon have been studied in 20 subjects (both of the subjects’ parents were diabetic or in case of only one
diabetic parent, the other showed a first degree familiarity of diabetes): 10 showed normal glucose tolerance (‘true prediabetics’)
and 10 impaired glucose tolerance (‘genetic chemical diabetes’). Mean insulin response to oral (100 g) and i.v. glucose load
(200 mg/kg followed by 20 mg/kg/min for 60 min) and to arginine infusion (25 g in 30 min) was normal in the prediabetics and
delayed and higher in the subjects with chemical diabetes as compared to the control group. Glucagon response to arginine
was higher, but not significantly, in prediabetics and in subjects with chemical diabetes. In both of these groups glucagon
suppression by glucose was not observed. The insulin/glucagon molar ratio was significantly reduced after glucose infusion
in these two groups. No correlation was found between insulin and glucagon secretion after arginine or glucose. A possible
alteration in the mechanism controlling glucagon secretion even in the earliest phases of diabetes is suggested.
This work was supported in part by C.N.R. (Consiglio Nazionale delle Ricerche), Roma, grant # CT 76.01345.04. |
| |
Keywords: | Arginine infusion Chemical diabetes Glucose infusion Insulin and glucagon secretion Insulin/glucagon molar ratio Potential diabetes |
本文献已被 SpringerLink 等数据库收录! |