老年抑郁症患者的脑正电子发射体层摄影术显像分析

目的 探讨老年抑郁症患者脑^18氟-脱氧葡萄糖（18^F-FDG）正电子发射体层摄影术（PET）显像的特点。方法 分别对6例老年抑郁症患者（GD组）及10名健康体检者（对照组）进行脑^18 F-FDGPET显像，按年龄、简易智力状态检查量表总分和性别构成配对，用统计参数图第2版软件比较两组间脑局部葡萄糖代谢的差别。结果 GD组较对照组在双侧尾状核、额下回、颞上回、额中回，右侧核外、额上回、舌回和左侧扣带回、中央前回等脑区局部葡萄糖代谢减低（均P〈0．005）。GD组无局部脑葡萄糖代谢增加的脑区。结论 老年抑郁症患者存在基底节区、前额叶、颞叶和边缘系统的局部葡萄糖代谢下降。

Analysis of brain position emission tomography mapping in geriatric depression patients

Objective To investigate brain ~(18)F-fluorodeoxyglucose(FDG) position emission tomography(PET) mapping in geriatric depression patients.Methods This is a case control study.PET with ~(18)F-FDG was performed in six geriatric depression patients and ten healthy controls.The two groups were matched with age,sex and the Mini-Mental State Examination(MMSE) score.The voxel level regional glucose metabolic rate were analyzed with the Statistical Parametric Mapping(SPM2) software.Results(The regional) glucose metabolism rates in bilateral caudate,superior temporal gyrus,inferior frontal gyrus,middle frontal gyrus,right extra-nuclear,superior frontal gyrus,lingual gyrus and left cingulate gyrus,superior temporal gyrus,sub-gyral and precentral gyrus were decreased in geriatric depression patients than in controls(P<0.005).There was no significant difference in brain regions with increased glucose metabolism between two groups.Conclusion These results suggest that the glucose metabolism in prefrontal lobes,temporal lobe,limbic system and basal ganglia is decreased in geriatric depressed patients.