| HIV感染者免疫状态及其与淋巴细胞周期变化关系探讨 |
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| 引用本文： | 曾华书,张世英,张勇,石向东,王晓辉,张燕. HIV感染者免疫状态及其与淋巴细胞周期变化关系探讨[J]. 中国热带医学, 2009, 9(7): 1203-1204 |
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| 作者姓名： | 曾华书 张世英 张勇 石向东 王晓辉 张燕 |
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| 作者单位： | 1. 深圳市福田区疾病预防控制中心,广东,深圳,518040
2. 深圳市疾病预防控制中心,广东,深圳,518020 |
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| 基金项目： | 深圳市福田区2007年科技局资助项目(CFTWS034) |
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| 摘 要： | 目的研究HIV感染不同阶段感染者与正常人免疫状态及淋巴细胞周期变化。方法利用流式细胞仪对正常人及HⅣ感染者CD4^＋CD8^＋、CD3＋T淋巴细胞绝对数、CD4^＋／CD8^＋比值及淋巴细胞周期进行检测。结果HIV感染者CD44T淋巴细胞数及CD4^＋／CD8^＋比值进行性减少，CD8^＋T淋巴细胞数在感染早期明显增加，在感染后期增加减弱；淋巴细胞周期在HIV感染者CD4^＋T淋巴细胞数正常范围内时受促进；当感染者CD4^＋T淋巴细胞数低于正常值范围时，淋巴细胞周期各期比例与健康对照组无差异。结论HIV感染后机体免疫功能及淋巴细胞周期随疾病进程发生异常变化，且淋巴细胞周期变化与CD8＋^＋淋巴细胞数变化趋势基本一致，提示细胞周期变化在CD8叮淋巴细胞数变化过程中可能起重要作用。
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| 关 键 词： | HIV 细胞周期 流式细胞术 T淋巴细胞亚群 |
The correlation of immunologic state with cycle variation of lymphocytes in HIV infected individuals |
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| ZENG Hua-shu,ZHANG Shi-ying,ZHANG Yong,et al.. The correlation of immunologic state with cycle variation of lymphocytes in HIV infected individuals[J]. China Tropical Medicine, 2009, 9(7): 1203-1204 |
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| Authors: | ZENG Hua-shu ZHANG Shi-ying ZHANG Yong et al. |
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| Affiliation: | Futian Ditrict Center for Disease Control and Prevention;Shenzhen 518040;Guangdong;P.R.China |
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| Abstract: | Objective To observe the cyclic changes of lymphocytes and the immunologic condition in normal persons and HIV positives.Methods The cylclic changes of lymphocytes and the counts of CD4 +T lymphocytes,CD8 +T lymphocyte,CD3 +T lymphocyte,CD4 +/CD8 + ratio in normal persons and HIV positives by flow cytometry.Results CD4+T lymphocyte count and the ratio of CD4+/CD8+ in HIV positives reduced continually,CD8+T lymphocyte count was higher in the earlier stage and reduced in the later stage.When CD4+T lymphocyte ... |
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| Keywords: | HIV Cell-cycle Flow cytometry T lymphocyte subset |
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