| 酒石酸长春瑞滨的合成 |
| |
| 引用本文： | 刘素云,阙日明.酒石酸长春瑞滨的合成[J].中国医药工业杂志,2010,41(9). |
| |
| 作者姓名： | 刘素云 阙日明 |
| |
| 作者单位： | 1. 北京科莱博医药开发有限责任公司,北京,102600
2. 上海睿智化学研究有限公司,上海,201203 |
| |
| 摘 要： | 长春质碱经间氯过氧苯甲酸氧化、三氟乙酐处理后,再与文多灵反应得到关键中间体脱水长春碱,其9'-位经1氯代苯并三唑氯代、四氟硼酸银处理缩环后,与酒石酸成盐,制得抗肿瘤药酒石酸长春瑞滨,总收率约12%.
|
| 关 键 词： | 长春瑞滨 长春质碱 文多灵 抗肿瘤药 合成 |
Synthesis of Vinorelbine Tartrate |
| |
| Authors: | LIU Suyun QUE Riming |
| |
| Institution: | LIU Suyun1,QUE Riming2 (1. Beijing Collab Pharma Co.,Ltd.,Beijing 102600,2. Shanghai Chempartner Co.,Shanghai 201203) |
| |
| Abstract: | Catharanthine was subsequently treated with m-chloroperoxybenzoic acid,trifluoroacetic anhydride,vindoline and NaBH4 to give anhydrovinblastine,which after 9'-chlortnation was treated with AgBF4,followed by salification of L-tartaric acid to obtain the antitumor agent vinorelbine tartrate with an overall yield of about 12%. |
| |
| Keywords: | vinorelbine catharanthine vindoline antitumor agent synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
