硫普罗宁治疗非酒精性脂肪肝炎临床观察

目的评价硫普罗宁治疗非酒精性脂肪性肝炎的临床疗效。方法将我院门诊的60例NASH肝炎患者随机分为两组，治疗组给予硫普罗宁片口服，对照组给予熊去氧胆酸口服，连用3个月，两组基本治疗相同。分别于用药前后观测患者的临床症状、肝功能和血脂指标。结果治疗结束后两组与治疗前相比均有明显改善（P〈0．01），而治疗组在肝功能和血脂方面的改善均优于对照组（P〈0．05），两组在综合疗效对比中，硫普罗宁组总有效率90．0％，熊去氧胆酸组总有效率73．4％，两组有显著性差异（P〈0．01）。结论硫普罗宁片能有效改善NASH患者的临床症状、肝功能和血脂指标，疗效确切。

Clinical Evaluation on the Effect of Tiopronin in Nonalcoholic Steatohepatitis

Objective To evaluate the effect of tiopronin in nonalcoholic stertohepatitis. Methods 60 patients of nonalcoholic stertohepatitis were enrolled and randomized into tiopronin and ursodesoxycholic acid groups. 30 patients were intravenous infused with tiopronin 200mg tid for three months,30 patients were intravenous infused with ursodesoxycholic acid 300mg tid for three months. The efficacy was evaluated with live function and hlood lipids from venous blood when pre-treatment and post-treatment respectively. Results After three months,the liver function of almost all of the patients were improved remarkably（P〈 0.01 ）. But as to the improvement of liver function and blood lipids, treatment group was much better than the control group（P〈 0.05）, the total efficiency of tiopronin group was 90.0% and ursodesoxycholic acid group 73.4%. In the comparative efficacy,the two groups had significant differences（ P〈 0.01 ）. Conclusion Tiopronin has remarkable effect in the patients with nonalcoholic stertohepatitis.