体力活动对结直肠癌发病影响的重庆地区大样本病例-对照研究

目的研究重庆地区人群结直肠癌发病危险与体力活动之间的关系.方法进行院内病例-对照研究,478名有效病例和838名对照均选自于2002年1月至2004年6月在第三军医大学3所附属医院住院治疗的重庆本地居民患者,并按年龄相差5岁以内、性别和居住地相同的条件进行配对.采用条件逻辑回归方法计算OR值,表示与疾病危险性的关联程度.结果重体力/极重体力劳动使直肠癌的危险显著增加(OR=1.49,95%CI:1.03～2.17),对结肠癌没有显著影响.而每日保持适当的直立活动时间(2～5 h/d)避免久坐(卧)则对直肠癌有显著保护效应 (OR=0.6,95%CI:0.36～0.99).10年前的体重指数、锻炼频率、睡眠时间等因素对直肠癌或结肠癌均无显著影响.结论体力活动程度对结直肠癌尤其是直肠癌的发病可能存在不同影响.

Physical activity and colorectal cancer: a case-control trial

Objective To study the relationship between physical activity and onset of colorectal cancer in Chongqing populations.Methods In the hospital-based case-control study comprising 478 cases and 838 controls,who were local inhabitants admitted to 3 affiliated hospitals of the third military medical university during Jan 2002 to Jun 2004,with gender,age within 5 years and living places matched,the informations about diet and life styles were collected in manner of investigator-interviewing.The risk of disease was represented by using Odds Ratio and the 95% confidence interval.Results Heavy/very heavy labour intensity significantly increased risk of rectum cancer(OR=1.49,95%CI: 1.03-2.17),but did not associated with colon cancer risk.Keeping activity for a proper time each day(2-5 h/d) had a significant protective effect against rectum cancer(OR=0.6,95%CI: 0.36-0.99).Other factors such as BMI of 10-year-ago,exercise frequency,sleeping time,did not show significant association to colon or rectum cancer.Conclusion Physical activity can be likely to affect risk of colorectal cancer,especially rectal caner in two opposite direction depending on different intensity of activity performed.