| 天门冬氨酸及精氨酸对烫伤小鼠细胞免疫变化的影响 |
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| 引用本文： | 郭长江,顾景范.天门冬氨酸及精氨酸对烫伤小鼠细胞免疫变化的影响[J].军事医学科学院院刊,1989,13(3):189-193. |
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| 作者姓名： | 郭长江 顾景范 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所，军事医学科学院卫生学环境医学研究所 |
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| 摘 要： | 本研究通过腹腔注射的方法,观察了天门冬氨酸、精氨酸对烫伤小鼠细胞免疫变化的影响.实验结果表明精氨酸腹腔注射同样能表现出显著的细胞免疫促进作用;天门冬氨酸也显示出减轻小鼠烫伤后胸腺萎缩、酯酶阳性细胞数减少、脾淋巴细胞转化反应能力受损的作用,但耳廓肿胀试验结果表明改善烫伤小鼠整体细胞免疫功能的效果并不明显.此外血清、脾脏游离氨基酸浓度分析结果初步排除了精氨酸或天门冬氨酸的作用是由于注射后血液及外周组织中浓度升高导致直接作用的可能性.
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| 关 键 词： | 天门冬氨酸 精氨酸 烫伤 细胞免疫 |
EFFECTS OF ASPARTATE AND ARGININE ON CELLULAR IMMUNITY IN BURNED MICE |
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| Guo Changjiang,Gu Jingfan Institute of Hygiene and Environmental Medicine,Academy of Military Medical Sciences.EFFECTS OF ASPARTATE AND ARGININE ON CELLULAR IMMUNITY IN BURNED MICE[J].Bulletin of the Academy of Military Medical Sciences,1989,13(3):189-193. |
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| Authors: | Guo Changjiang Gu Jingfan Institute of Hygiene and Environmental Medicine Academy of Military Medical Sciences |
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| Abstract: | In this study,the immunostimulating action of arginine was further confirmed by i.p.injection in burned mice.The i.p. administration of aspartate had a beneficial effect on cellular immunity.It minimized thymic involution,increased ANAE~+ lympnocytes in peripheral blood,and augmented mitogenic response of splenic lymphocytes.However,the result of ear swelling test indicated that aspartate has no significant effect on the function of the whole cellular immune system.The possible reason is discussed. |
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| Keywords: | aspartate arginine burn cellular immunity |
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