Delayed histological changes in cutaneous portion of pectoralis major flaps employed in upper aero-digestive tract reconstruction |
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Authors: | Fábio Roberto Pinto Jossi L. Kanda Mariana T. Diniz Cláudia P. Santos Deborah K. Zveibil |
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Affiliation: | 1.Department of Head and Neck Surgery,Hospital de Ensino da Faculdade de Medicina do ABC,S?o Bernardo do Campo,Brazil;2.Department of General Surgery,Hospital de Ensino da Faculdade de Medicina do ABC,S?o Bernardo do Campo,Brazil;3.Pathology and Immunohistochemistry Service,Laboratório APC,S?o Paulo,Brazil;4.Department of Pathology,Faculdade de Medicina do ABC,Santo André,Brazil;5.S?o Paulo,Brazil |
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Abstract: | Our aim was to determine whether histological changes occur in the cutaneous portion of pectoralis major flaps employed for upper aero-digestive tract reconstruction and, if present, to characterize these changes and try to infer their cause. Seven patients submitted to repair of aero-digestive tract defects secondary to cancer resection with pectoralis major myocutaneous flap were included in this study. All patients received adjuvant radiotherapy. Biopsies were taken from: the cutaneous portion of the flap; buccal mucosa; irradiated neck skin and chest skin opposite the donor site. Histological changes toward a “mucosalization” occur in the cutaneous portion of the pectoralis major flaps, characterized by disappearance of the horny layer or a reduction of its thickness and a decrease of the amount of cutaneous appendages. These changes are probably a result of continuous exposure to the intraoral environment in association with radiotherapy effects and may represent an advantageous adaptation for the patient. |
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Keywords: | Surgical flaps Histology Skin Mouth mucosa |
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