| 脂毒性心肌病的发病机制及治疗进展 |
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| 引用本文： | 李传保,卜培莉. 脂毒性心肌病的发病机制及治疗进展[J]. 心血管病学进展, 2007, 28(5): 774-776 |
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| 作者姓名： | 李传保 卜培莉 |
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| 作者单位： | 1. 教育部和卫生部心血管重构和功能研究重点实验室,山东大学齐鲁医院急诊科,山东,济南,250012
2. 教育部和卫生部心血管重构和功能研究重点实验室,山东大学齐鲁医院心内科,山东,济南,250012 |
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| 摘 要： | 心肌游离脂肪酸的摄入和利用的失协调导致心肌中脂质积聚并进而引起脂毒性心肌病。脂质通过何种机制导致心肌功能的改变,以及如何来干预脂毒性心肌病成为当今心血管领域倍受关注的研究方向。现就脂毒性心肌病的发病机制及治疗进展做一综述。
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| 关 键 词： | 游离脂肪酸 脂毒性 细胞凋亡 瘦素 |
| 文章编号： | 1004-3934（2007）05-0774-03 |
| 修稿时间： | 2006-11-232007-02-28 |
Pathogenesis and Therapy of Lipotoxic Cardiomyopathy |
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| LI Chuan-bao,BU Pei-li. Pathogenesis and Therapy of Lipotoxic Cardiomyopathy[J]. Advances in Cardiovascular Diseases, 2007, 28(5): 774-776 |
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| Authors: | LI Chuan-bao BU Pei-li |
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| Affiliation: | Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China |
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| Abstract: | Mismatches between myocardial fatty acid uptake and utilization lead to the accumulation of cardiotoxic lipid species,and cause lipotoxic cardiomyopathy.Recent cardiovascular research has focused on how lipid accumulation contributes to cardiomyopathy,and on how lipotoxic cardiomyopathy can be prevented.This article discusses the mechanisms of pathogenesis and therapy of lipotoxic cardiomyopathy. |
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| Keywords: | free fatty acid lipotoxic apoptosis leptin |
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