| 天麻首乌片治疗偏头痛的作用机理的实验研究 |
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| 引用本文： | 刘朝晖,周常权,杨宝凡,韩东,廖福龙. 天麻首乌片治疗偏头痛的作用机理的实验研究[J]. 中成药, 2002, 24(12): 952-956 |
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| 作者姓名： | 刘朝晖 周常权 杨宝凡 韩东 廖福龙 |
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| 作者单位： | 1. 湖南德海制药有限公司,湖南,常德,415003
2. 中国中医药研究院中药研究所药理室,北京 |
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| 摘 要： | 目的：从血管内皮细胞的角度寻找天麻首乌片与偏头痛的联系。方法：体外培养大鼠脑微血管内皮细胞中加入含天麻首乌片的血清并观察培养液中NO和ET的含量变化以及ET mRNA和iNOSmRNA表达的影响。结果：天麻首乌片显著下调iNOSmRNA,rCMECs和ETmRNA表达，降低培养液中NO和ET的含量。结论：天麻首乌片可降低脑鼠微血管内皮细胞的凋亡达到治疗偏头痛的作用。
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| 关 键 词： | 天麻首乌片 治疗 偏头痛 作用机理 实验研究 |
| 文章编号： | 1001-1528(2002)12-0952-04 |
| 修稿时间： | 2001-12-19 |
Effect of Tianmashouwu Tablet on migraine |
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| LIU Zhao hui ,ZHOU Chang quan ,YANG Bao fan ,HAN Dong ,LIAO Fu long. Effect of Tianmashouwu Tablet on migraine[J]. Chinese Traditional Patent Medicine, 2002, 24(12): 952-956 |
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| Authors: | LIU Zhao hui ZHOU Chang quan YANG Bao fan HAN Dong LIAO Fu long |
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| Affiliation: | LIU Zhao hui 1,ZHOU Chang quan 1,YANG Bao fan 1,HAN Dong 2,LIAO Fu long 2 |
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| Abstract: | Objective: To discover the connection between migraine and Tianmashouwu Tablet (TMT) in endothelial cell perspective. Methods: Serum containing TMT was added to rat's cerebral capilary endothelial cell's culture to observe the changes of NO and ET, and effect on express of ETmRNA and iNOSmRNA. Results: Levels of iNOSmRNA, rCMECs and ETmRNA were all downregulated, and contents of both NO and ET were decreased. Conclusions: TMT is effective in protection against rCMECs induced apoptosis, and has a therapeutic effect on migraine. |
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| Keywords: | Tianmashouwu Tablet ET NO migraine |
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